rs4886238

This variant is located in the TDRD3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

age at menopause

Day FR et al. “Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.” Nature Genetics 47(11):1294-1303 (2015)

Allele G

OR 0.18

p 3.0e-16

N 69,626

Large GWAS

European

Stolk L et al. “Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.” Nature Genetics 44(3):260-8 (2012)

Allele G

OR 0.17

p 1.0e-10

N 38,968

Large GWAS

European

About TDRD3

Enables chromatin binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in DNA topological change. Located in Golgi apparatus; cytosol; and nucleus. Part of DNA topoisomerase III-beta-TDRD3 complex. [provided by Alliance of Genome Resources, Apr 2025]

View all TDRD3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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