rs489693

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lean body mass

Feng GJ et al. “Identification of pleiotropic loci underlying hip bone mineral density and trunk lean mass.” Journal of Human Genetics 66(3):251-260 (2021)

Allele C

OR 0.05

p 9.0e-113

N 11,335

Large GWAS

multi-ancestry

coffee consumption measurement, tea consumption measurement

Said MA et al. “Associations of Observational and Genetically Determined Caffeine Intake With Coronary Artery Disease and Diabetes Mellitus.” Journal of the American Heart Association 9(24):e016808 (2020)

Allele C

OR 0.02

p 1.0e-12

N 362,316

Large GWAS

European

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)

Allele A

OR 6.09

p 1.0e-9

N 449,484

Meta-analysisLarge GWAS

European

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Research that mentions this SNP (1)

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Association Between Common Variants Near the Melanocortin 4 Receptor Gene and Severe Antipsychotic Drug–Induced Weight Gain

AssociationN=344Malhotra AK et al.(2012)· Archives of General Psychiatry

Genome-wide association study of 139 antipsychotic-naïve pediatric patients identified common variants near the MC4R gene (melanocortin 4 receptor) on chromosome 18 associated with severe antipsychotic drug-induced weight gain. The most significant SNPs (rs489693, rs646749, rs12970134) showed p-values ranging from 2.80E-07 to 3.26E-06 in the discovery cohort and replicated in three additional cohorts (n=73, 40, 92). Minor allele homozygotes of rs489693 exhibited significantly greater increases in body fat mass, triglycerides, leptin, insulin, and HOMA-IR.

Traits studied:Antipsychotic-induced weight gainBody mass index (BMI) changeFat massGlucoseHDL cholesterolHOMA-IRInsulinLDL cholesterolLeptinTotal cholesterolTriglycerides

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.