rs4908760

This variant is located in the RERE gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Vitiligo

Jin Y et al. “Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.” The New England Journal of Medicine 362(18):1686-97 (2010)
Allele G
OR 1.36
p 7.0e-15
N 4,021
Large GWAS
European

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)
Allele A
OR 5.83
p 6.0e-9
N 1,508,659
Large GWAS
multi-ancestry

smoking initiation

Erzurumluoglu AM et al. “Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.” Molecular Psychiatry 25(10):2392-2409 (2020)
Allele A
OR 0.01
p 2.0e-8
N 346,813
Meta-analysisLarge GWAS
multi-ancestry

About RERE

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

View all RERE variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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