rs4916723

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

alcohol consumption quality

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele C
OR 0.01
p 6.0e-34
N 2,965,643
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
Zhou H et al. “Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.” Nature Neuroscience 23(7):809-818 (2020)
Allele C
OR 0.01
p 9.0e-10
N 972,915
Meta-analysisLarge GWAS
European
Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele C
OR 0.01
p 2.0e-11
N 941,280
Large GWAS
European
Evangelou E et al. “New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.” Nature Human Behaviour 3(9):950-961 (2019)
Allele C
OR 0.01
p 2.0e-10
N 480,842
Large GWAS
European
Karlsson Linnér R et al. “Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.” Nature Genetics 51(2):245-257 (2019)
Allele C
OR 0.02
p 1.0e-11
N 414,343
Large GWAS
European

attention deficit hyperactivity disorder

van der Laan CM et al. “Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes.” Nature Genetics 57(10):2427-2435 (2025)
Allele C
OR 0.02
p 6.0e-16
N 299,017
Meta-analysisLarge GWAS
European
Demontis D et al. “Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.” Nature Genetics 55(2):198-208 (2023)
Allele C
OR 0.92
p 9.0e-15
N 225,534
Large GWAS
European
LaBianca S et al. “Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder.” Nature Genetics 56(2):234-244 (2024)
Allele C
OR 1.10
p 8.0e-9
N 24,734
Large GWAS
European

taste liking measurement

May-Wilson S et al. “Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.” Nature Communications 13(1):2743 (2022)
Allele C
OR 0.03
p 2.0e-13
N 159,554
Large GWAS
European

attention deficit hyperactivity disorder, Cannabis use

Soler Artigas M et al. “Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality.” Molecular Psychiatry 25(10):2493-2503 (2020)
Allele C
OR 1.08
p 2.0e-9
N 83,129
Large GWAS
European

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 5.61
p 2.0e-8
N 449,484
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder
Meta-analysisN=133,650Lars Libuda et al.(2021)· European Journal of Nutrition

A bidirectional two-sample Mendelian randomization study examining the causal relationship between 25-hydroxyvitamin D levels and attention-deficit/hyperactivity disorder (ADHD). Using 79,366 European individuals for vitamin D GWAS data and 19,099 ADHD cases with 34,194 controls, the study found no evidence of a causal effect of vitamin D on ADHD (IVW β = -0.043, p = 0.833) or reverse causality. Although rs12785878 showed a nominal association with increased ADHD risk at higher vitamin D levels (p = 0.024), this did not survive multiple testing correction.

Traits studied:Attention-deficit/hyperactivity disorder (ADHD)Vitamin D levels (25-hydroxyvitamin D)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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