rs4923457

This is a intron variant variant in the BDNF-AS gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

schizophrenia

Trubetskoy V et al. “Mapping genomic loci implicates genes and synaptic biology in schizophrenia.” Nature 604(7906):502-508 (2022)
Allele A
OR 1.05
p 4.0e-8
N 175,799
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Effect of DISC1 SNPs on brain structure in healthy controls and patients with a history of psychosis
ReviewN=113Anna K. Kähler et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This systematic review and validation study examined psychosis-associated SNPs and their effects on brain volumetry in 113 subjects (schizophrenia, bipolar disorder, at-risk mental state, and healthy controls). Of 25 studies identified in the systematic review implicating 7 SNPs in 5 genes, the authors tested these variants using voxel-based morphometry. They found FWER-corrected associations for CACNA1C rs769087-A with larger bilateral hippocampus and thalamus white matter (p = 0.026 and p = 0.036) and with larger superior frontal gyrus volume. Higher replication concordance was found for CACNA1C, ZNF804A, and BDNF variants, supporting their involvement in psychosis and brain structure.

Traits studied:Bipolar disorderBrain volumetryGrey matter volumePsychotic disordersSchizophreniaWhite matter volume
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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