rs4953152
This variant is located in the SIX3 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
cerebral cortex area attribute
Shadrin AA et al. “Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.” Neuroimage 244:118603 (2021)
Allele A
OR —
p 2.0e-13
N 35,657
Large GWAS
European
irritability measurement
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.13
p 9.0e-10
N 366,726
Large GWAS
European
alcohol consumption quality
Kember RL et al. “Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.” The American Journal of Psychiatry 180(8):584-593 (2023)
Allele A
OR 5.53
p 3.0e-8
N 409,630
Large GWAS
multi-ancestry
substance-related disorder
Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)
Allele A
OR 7.43
p 1.0e-13
N 1,699,295
Large GWAS
multi-ancestry
taste liking measurement
May-Wilson S et al. “Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.” Nature Communications 13(1):2743 (2022)
Allele A
OR 0.02
p 8.0e-11
N 159,527
Large GWAS
European
▶ClinVar annotation
Benign★★★☆
2 submitters1 publicationAbout SIX3
This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]
View all SIX3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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