rs4977575

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GWAS Catalog Trait Associations (19)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cardiovascular disease biomarker measurement

Gummesson A et al. “A genome-wide association study of imaging-defined atherosclerosis.” Nature Communications 16(1):2266 (2025)
Allele G
OR 0.33
p 1.0e-66
N 24,811
Large GWAS
European

intermediate coronary syndrome

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.18
p 4.0e-57
N 434,858
Major Consortium StudyLarge GWAS
European

coronary artery calcification

Kavousi M et al. “Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.” Nature Genetics 55(10):1651-1664 (2023)
Allele C
OR 0.26
p 7.0e-47
N 36,720
Large GWAS
multi-ancestry

congestive heart failure

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.06
p 4.0e-25
N 429,672
Major Consortium StudyLarge GWAS
European

systolic blood pressure

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 4.0e-25
N 425,711
Major Consortium StudyLarge GWAS
European

coronary artery disease

Klarin D et al. “Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.” Nature Genetics 49(9):1392-1397 (2017)
Allele G
OR 1.24
p 5.0e-23
N 120,286
Major Consortium StudyLarge GWAS
multi-ancestry

Chest pain

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.05
p 8.0e-23
N 390,081
Major Consortium StudyLarge GWAS
European

pulse pressure measurement

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)
Allele G
OR 0.16
p 8.0e-20
N 1,028,980
Large GWAS
multi-ancestry

device complication

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.16
p 9.0e-20
N 443,178
Major Consortium StudyLarge GWAS
European

systolic heart failure

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.07
p 6.0e-19
N 438,433
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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