rs530885291
This variant is located in the SIDT2 gene.
▶GWAS Catalog Trait Associations (18)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (18)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
lactadherin measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.58
p 4.0e-20
N 47,745
Large GWAS
European
1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6) measurement
Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 1.10
p 6.0e-20
N 14,296
Large GWAS
European
high density lipoprotein cholesterol measurement
Nagy R et al. “Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.” Genome Medicine 9(1):23 (2017)
Allele A
OR 1.03
p 1.0e-19
N 26,086
Major Consortium StudyLarge GWAS
European
1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) measurement
Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 1.03
p 1.0e-17
N 14,296
Large GWAS
European
1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) measurement
Hysi PG et al. “Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels.” Metabolites 12(1) (2022)
Allele A
OR 0.98
p 5.0e-14
N 8,809
Large GWAS
European
1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) measurement
Hysi PG et al. “Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels.” Metabolites 12(1) (2022)
Allele A
OR 0.97
p 1.0e-13
N 8,809
Large GWAS
European
platelet component distribution width
Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.22
p 2.0e-13
N 408,112
Large GWAS
European
lysophosphatidylethanolamine 18:0 measurement
Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)
Allele A
OR 1.65
p 5.0e-13
N 4,492
Large GWAS
European
free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.37
p 6.0e-13
N 136,016
Large GWAS
multi-ancestry
glycerophospholipid measurement
Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)
Allele A
OR 1.56
p 7.0e-12
N 4,492
Large GWAS
European
About SIDT2
Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and RNA transmembrane transporter activity. Involved in RNA transport. Located in lysosomal membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all SIDT2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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