rs546738

This is a intron variant variant in the NLGN1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total lipids in large HDL

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 4.0e-14

N 450,015

Large GWAS

multi-ancestry

Headache, type 2 diabetes mellitus

Islam MR et al. “Genetic Overlap Analysis Identifies a Shared Etiology between Migraine and Headache with Type 2 Diabetes.” Genes 13(10) (2022)

Allele G

OR 1.03

p 3.0e-10

N 1,258,523

Large GWAS

European

About NLGN1

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

View all NLGN1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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