rs55678414

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele G

OR 0.04

p 3.0e-24

N 1,212,859

Large GWAS

European

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele G

OR 0.72

p 7.0e-22

N 526,001

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.02

p 7.0e-17

N 485,664

Large GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.03

p 1.0e-11

N 394,642

Large GWAS

European

Teixeira SK et al. “Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.” Scientific Reports 14(1):28123 (2024)

Allele G

OR 0.70

p 1.0e-9

N 286,581

Large GWAS

European

Schoeler T et al. “Participation bias in the UK Biobank distorts genetic associations and downstream analyses.” Nature Human Behaviour 7(7):1216-1227 (2023)

Allele G

OR 0.63

p 2.0e-8

N 275,793

Major Consortium StudyLarge GWAS

European

pulse pressure measurement

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.45

p 8.0e-20

N 130,777

Large GWAS

multi-ancestry

Pozarickij A et al. “Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.” Nature Communications 15(1):6265 (2024)

Allele T

OR 0.64

p 9.0e-20

N 100,453

Large GWAS

East Asian

Pirruccello JP et al. “The Genetic Determinants of Aortic Distention.” Journal of the American College of Cardiology 81(14):1320-1335 (2023)

Allele T

OR 0.08

p 3.0e-8

N 37,672

Large GWAS

European, NR

descending aorta diameter

Pirruccello JP et al. “Deep learning enables genetic analysis of the human thoracic aorta.” Nature Genetics 54(1):40-51 (2022)

Allele T

OR —

β 0.088

p 7.0e-15

N 39,688

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs55678414

GWAS Catalog Trait Associations (3)

systolic blood pressure

pulse pressure measurement

descending aorta diameter

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