rs55705857

This is a intron variant variant in the CCDC26 gene.

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GWAS Catalog Trait Associations (12)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

central nervous system cancer

Kinnersley B et al. “Genome-wide association study identifies multiple susceptibility loci for glioma.” Nature Communications 6:8559 (2015)

Allele G

OR 3.60

p 1.0e-62

N 9,799

Large GWAS

European

brain attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)

Allele G

OR 14.78

p 2.0e-49

N 33,748

Large GWAS

European

lymphocyte:monocyte ratio

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele A

OR —

p 1.0e-22

N 234,184

Large GWAS

European

cortical thickness

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)

Allele G

OR 7.94

p 2.0e-15

N 33,748

Large GWAS

European

cerebral cortex area attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)

Allele G

OR 7.79

p 7.0e-15

N 33,748

Large GWAS

European

brain connectivity attribute

Sha Z et al. “Genetic architecture of the white matter connectome of the human brain.” Science Advances 9(7):eadd2870 (2023)

Allele A

OR 6.85

p 7.0e-12

N 30,810

Large GWAS

European

age at onset, glioblastoma multiforme

Quinn T. Ostrom et al. “Age‐specific genome‐wide association study in glioblastoma identifies increased proportion of ‘lower grade glioma’‐like features associated with younger age” International Journal of Cancer (2018)

Allele G

OR 1.76

p 9.0e-11

N 15,094

Large GWAS

white matter integrity

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)

Allele G

OR 0.14

p 3.0e-10

N 20,860

Major Consortium StudyLarge GWAS

European

mean fractional anisotropy measurement

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)

Allele G

OR 0.13

p 1.0e-9

N 20,860

Major Consortium StudyLarge GWAS

European

central nervous system cancer, glioma

Melin BS et al. “Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.” Nature Genetics 49(5):789-794 (2017)

Allele G

OR 1.99

p 1.0e-78

N 30,659

Large GWAS

European

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ClinVar annotation

Risk Factor

1 submitter1 publication

Glioma susceptibility 7

View on ClinVar →

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Research that mentions this SNP (2)

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Age‐specific genome‐wide association study in glioblastoma identifies increased proportion of ‘lower grade glioma’‐like features associated with younger age

AssociationN=15,094Quinn T. Ostrom et al.(2018)· International Journal of Cancer

Age-stratified genome-wide association study of 4,512 glioblastoma cases and 10,582 controls identified age-specific genetic effects on disease susceptibility. SNPs at 7p11.2 (rs723527, rs11979158 near EGFR) showed increased association in older individuals (age 54+, OR=1.28-1.42), while a lower-grade glioma-associated SNP at 8q24.21 (rs55705857) was associated with younger diagnosis (age 18-53, OR=1.76, p=9.30×10−11). IDH1/2 mutations occurred in 15% of younger GBM cases versus 0.8-2.1% in older cases, suggesting many younger cases represent 'secondary GBM' with LGG-like features.

Traits studied:Age-at-diagnosis in glioblastomaGlioblastomaGlioma

PubMed DOI Metascience Observatory

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ATG12 expression quantitative trait loci associated with head and neck squamous cell carcinoma risk in a Chinese Han population

AssociationN=1,056Xueyao Song et al.(2018)· Molecular Carcinogenesis

This study investigated the association of MGMT enhancer variant rs11016629 with glioma susceptibility and progression in 402 patients and 654 controls. The TG genotype was associated with increased glioma risk (OR=1.41, 95% CI 1.03-1.93, P=0.034), particularly in WHO grade IV tumors (OR=1.59, P=0.023). In patients who underwent gross total resection, carriers with TG/TT genotypes had worse progression-free survival (HR=2.66, 95% CI 1.23-5.79, P=0.014) compared to GG carriers.

Traits studied:GlioblastomaGliomaHigh-grade gliomaWHO grade IV glioma

PubMed DOI Metascience Observatory

About CCDC26

Implicated in brain cancer and high grade glioma. [provided by Alliance of Genome Resources, Jul 2025]

rs55705857

GWAS Catalog Trait Associations (12)

central nervous system cancer

brain attribute

lymphocyte:monocyte ratio

cortical thickness

cerebral cortex area attribute

brain connectivity attribute

age at onset, glioblastoma multiforme

white matter integrity

mean fractional anisotropy measurement

central nervous system cancer, glioma

ClinVar annotation

Research that mentions this SNP (2)

About CCDC26

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