rs570524

This is a intron variant variant in the TTC39B gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

HDL cholesterol change measurement, physical activity

Kilpeläinen TO et al. “Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.” Nature Communications 10(1):376 (2019)

Allele T

OR —

p 3.0e-20

N 120,979

Large GWAS

multi-ancestry

depressive symptom measurement, non-high density lipoprotein cholesterol measurement

Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)

Allele T

OR —

β 0.001

p 2.0e-9

N 89,939

Large GWAS

European

About TTC39B

Predicted to be involved in several processes, including cholesterol homeostasis; negative regulation of cholesterol storage; and regulation of cholesterol efflux. [provided by Alliance of Genome Resources, Jul 2025]

View all TTC39B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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