rs574584
This is a regulatory region variant variant in the ADRA1A gene.
▶Research that mentions this SNP (4)
▶The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigoAssociationN=420Jianlong Han et al.(2018)· Journal of Clinical Laboratory Analysis
Case-control study of 216 cervical vertigo patients and 204 controls identifying SNPs in ADRA1A, ADRB1, ADRB2, and NPY genes significantly associated with cervical vertigo risk (ORs 0.62-2.07) and clinical prognosis markers (JOA score and recovery rate). ADRA1A rs3802241 showed OR=2.07 for disease risk and protective effect on prognosis; NPY variants predicted recovery outcomes.
▶Association between catechol‐O‐methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case–control studyAssociationN=426Park DJ et al.(2016)· European Journal of Pain
This international doctoral thesis examined gene-physical activity interactions in fibromyalgia through six studies analyzing 64 SNPs across 34 candidate genes in Spanish women. The case-control study (314 fibromyalgia cases vs. 112 controls) identified associations of rs841 (GCH1), rs1799971 (OPRM1), and rs2097903 (COMT) with fibromyalgia susceptibility (p=0.04, p=0.02, and p=0.04 respectively). Cross-sectional studies (n=274-276 fibromyalgia patients) found that SCN9A rs4453709 and other genetic polymorphisms interacted with physical activity to influence pain, fatigue, and resilience outcomes.
▶Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domainsAssociationN=275Gilberto Vargas‐Alarcón et al.(2009)· Arthritis & Rheumatism
Case-control study examining adrenergic receptor gene polymorphisms in fibromyalgia patients from Mexican and Spanish populations. The beta(2)-AR AC haplotype was a significant risk factor (42.1% in Mexican patients vs 30.5% controls, p=0.04; 50.4% Spanish patients vs 40.0% controls, p=0.05). The rs574584 GG genotype in Mexican patients associated with higher disability scores, morning stiffness, and fatigue.
▶A Linkage Disequilibrium between Genes at the Serine Protease Inhibitor Gene Cluster on Chromosome 14q32.1 Is Associated with Wegener's GranulomatosisAssociationN=350Stefan Borgmann et al.(2001)· Clinical Immunology
This doctoral thesis conducted multiple candidate gene association studies in 274-426 southern Spanish women with fibromyalgia to investigate gene-physical activity/sedentary behavior interactions with pain, fatigue, and resilience. Study III identified rs841 (GCH1) GG genotype (OR=0.61, p=0.04) and rs2097903 (COMT) AT/TT genotypes (OR=1.66, p=0.04) associated with fibromyalgia susceptibility, and confirmed rs1799971 (OPRM1) GG genotype (OR=0.58, p=0.02) confers genetic risk. Study IV found rs6311/rs6313 (HTR2A) polymorphisms individually associated with algometer pain score, and gene-sedentary behavior interactions involving rs4680/rs165599 (COMT), rs1383914 (ADRA1A), rs12994338/rs4453709 (SCN9A), and rs6860 (CHMP1A) significantly associated with pain outcomes. SCN9A emerged as most robust gene for fibromyalgia phenotype.
About ADRA1A
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
View all ADRA1A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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