ADRA1A
adrenoceptor alpha 1A
Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Known Variants46 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3802241 | 8:26,623,384 | G/A | intron variant | — |
| rs766671226 | 8:26,627,680 | C/T | — | uncertain significance |
| rs958681910 | 8:26,627,746 | G/C | — | uncertain significance |
| rs771722367 | 8:26,627,799 | C/T | — | uncertain significance |
| rs576498291 | 8:26,627,832 | A/G | — | uncertain significance |
| rs142415576 | 8:26,627,864 | A/C | — | benign |
| rs1438457309 | 8:26,627,979 | G/C | — | uncertain significance |
| rs965188288 | 8:26,628,027 | C/T | — | uncertain significance |
| rs1048101 | 8:26,628,028 | A/G | missense variant | — |
| rs1806064105 | 8:26,628,036 | T/G | — | uncertain significance |
| rs748644622 | 8:26,658,760 | C/T | — | — |
| rs13278849 | 8:26,714,874 | G/A | intron variant | — |
| rs17426222 | 8:26,717,817 | C/T | intron variant | — |
| rs4732957 | 8:26,718,880 | A/G | — | — |
| rs4732682 | 8:26,720,893 | C/T | intron variant | — |
| rs573514 | 8:26,721,281 | A/T | — | — |
| rs148938279 | 8:26,721,610 | G/A | — | uncertain significance |
| rs2536427310 | 8:26,721,618 | A/G | — | uncertain significance |
| rs61757007 | 8:26,721,668 | C/A | — | benign |
| rs775965765 | 8:26,721,744 | A/G | — | uncertain significance |
| rs140371319 | 8:26,721,750 | C/T | — | uncertain significance |
| rs7833704 | 8:26,721,764 | G/T | — | benign |
| rs745411477 | 8:26,721,814 | C/G | — | uncertain significance |
| rs201098896 | 8:26,721,826 | C/T | — | uncertain significance |
| rs200422473 | 8:26,721,841 | G/C | — | uncertain significance |
| rs2229125 | 8:26,721,888 | A/C | missense variant | — |
| rs371939148 | 8:26,721,921 | G/T | — | uncertain significance |
| rs755834390 | 8:26,722,012 | T/C | — | uncertain significance |
| rs2229124 | 8:26,722,025 | G/C | — | benign |
| rs890568698 | 8:26,722,026 | G/A | — | uncertain significance |
| rs61757009 | 8:26,722,027 | C/A | — | benign |
| rs1813737314 | 8:26,722,035 | C/G | — | uncertain significance |
| rs914665795 | 8:26,722,083 | G/A | — | uncertain significance |
| rs1372847806 | 8:26,722,111 | T/G | — | uncertain significance |
| rs776269898 | 8:26,722,198 | C/A | — | uncertain significance |
| rs758905419 | 8:26,722,260 | G/A | — | uncertain significance |
| rs756351673 | 8:26,722,275 | G/T | — | uncertain significance |
| rs2536434133 | 8:26,722,312 | A/G | — | uncertain significance |
| rs2536434151 | 8:26,722,314 | T/G | — | uncertain significance |
| rs376184998 | 8:26,722,332 | G/A | — | uncertain significance |
| rs186663065 | 8:26,722,345 | T/C | — | uncertain significance |
| rs2536435511 | 8:26,722,465 | C/A | — | uncertain significance |
| rs1383914 | 8:26,723,049 | T/C | upstream gene variant | — |
| rs574584 | 8:26,723,684 | C/T | regulatory region variant | — |
| rs573542 | 8:26,723,818 | C/G | — | — |
| rs3808585 | 8:26,724,326 | C/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.