rs5758265

This variant is located in the L3MBTL2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

depressive symptom measurement

Turley P et al. “Multi-trait analysis of genome-wide association summary statistics using MTAG.” Nature Genetics 50(2):229-237 (2018)

Allele G

OR 0.01

p 1.0e-9

N 354,862

Large GWAS

European

major depressive disorder

Wray NR et al. “Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.” Nature Genetics 50(5):668-681 (2018)

Allele A

OR 1.03

p 8.0e-9

N 480,359

Large GWAS

European

About L3MBTL2

Enables methylated histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including ectoderm development; stem cell differentiation; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

View all L3MBTL2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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