rs587777005
This variant is located in the LGR4 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
testosterone measurement
Venkatesh SS et al. “Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum.” Nature Genetics 57(5):1107-1118 (2025)
Allele A
OR 1.03
p 2.0e-13
N 246,862
Large GWAS
European, South Asian
▶ClinVar annotation
Association
1 submitter1 publicationBone mineral density quantitative trait locus 17
View on ClinVar →About LGR4
The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]
View all LGR4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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