LGR4
leucine rich repeat containing G protein-coupled receptor 4
Summary
The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]
Known Variants81 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs202048946 | 11:27,389,448 | C/T | — | uncertain significance |
| rs752281610 | 11:27,389,484 | G/A | — | uncertain significance |
| rs956297202 | 11:27,389,503 | C/A | — | uncertain significance |
| rs964878789 | 11:27,389,559 | G/T | — | uncertain significance |
| rs1484489486 | 11:27,389,595 | G/T | — | uncertain significance |
| rs1862802891 | 11:27,389,629 | A/C | — | uncertain significance |
| rs72887882 | 11:27,389,681 | T/C | — | likely benign |
| rs765685987 | 11:27,389,695 | C/G | — | uncertain significance |
| rs1862804244 | 11:27,389,701 | C/T | — | uncertain significance |
| rs2494769146 | 11:27,389,734 | C/T | — | uncertain significance |
| rs34804482 | 11:27,389,739 | C/T | — | pathogenic |
| rs763158641 | 11:27,389,861 | G/A | — | likely benign |
| rs140875391 | 11:27,389,890 | C/G | — | uncertain significance |
| rs199575399 | 11:27,389,898 | G/T | — | uncertain significance |
| rs138381781 | 11:27,389,978 | C/T | — | likely benign |
| rs767863557 | 11:27,390,002 | A/G | — | likely benign |
| rs149204548 | 11:27,390,022 | C/T | — | benign |
| rs772615898 | 11:27,390,101 | A/G | — | likely benign |
| rs369897268 | 11:27,390,168 | G/A | — | uncertain significance |
| rs1015071415 | 11:27,390,199 | G/A | — | uncertain significance |
| rs772683855 | 11:27,390,214 | C/T | — | uncertain significance |
| rs7125959 | 11:27,390,220 | T/C | — | benign |
| rs148147363 | 11:27,390,255 | C/G | — | uncertain significance |
| rs772737034 | 11:27,390,300 | T/G | — | uncertain significance |
| rs748467080 | 11:27,390,424 | T/C | — | uncertain significance |
| rs770003664 | 11:27,390,427 | C/T | — | uncertain significance |
| rs771062877 | 11:27,390,443 | G/C | — | likely benign |
| rs369900849 | 11:27,390,486 | G/C | — | uncertain significance |
| rs35947785 | 11:27,390,488 | T/C | — | benign |
| rs2494772671 | 11:27,390,643 | G/C | — | uncertain significance |
| rs1252250185 | 11:27,390,660 | C/T | — | uncertain significance |
| rs182255585 | 11:27,390,699 | A/C | — | benign |
| rs79076592 | 11:27,391,525 | T/C | intron variant | — |
| rs944266223 | 11:27,393,215 | G/A | — | uncertain significance |
| rs766725576 | 11:27,393,851 | G/A | — | uncertain significance |
| rs778872167 | 11:27,393,877 | T/A | — | uncertain significance |
| rs369982748 | 11:27,395,188 | G/A | — | uncertain significance |
| rs1233701317 | 11:27,395,556 | T/C | — | uncertain significance |
| rs1862979048 | 11:27,397,862 | T/C | — | uncertain significance |
| rs764047833 | 11:27,397,869 | T/C | — | likely benign |
| rs2494787392 | 11:27,397,876 | G/A | — | uncertain significance |
| rs371443871 | 11:27,397,906 | C/T | — | likely benign |
| rs140395327 | 11:27,397,907 | G/A | — | uncertain significance |
| rs117543292 | 11:27,398,727 | A/C | — | benign |
| rs2494789439 | 11:27,398,748 | T/C | — | uncertain significance |
| rs1296666966 | 11:27,400,249 | C/G | — | uncertain significance |
| rs770556748 | 11:27,400,299 | T/C | — | uncertain significance |
| rs371742671 | 11:27,400,302 | T/C | — | uncertain significance |
| rs575879732 | 11:27,401,820 | A/T | — | uncertain significance |
| rs138266389 | 11:27,401,856 | C/G | — | uncertain significance |
| rs750714025 | 11:27,401,860 | T/C | — | uncertain significance |
| rs1484342153 | 11:27,402,199 | T/C | — | uncertain significance |
| rs372950771 | 11:27,402,218 | C/T | — | uncertain significance |
| rs2494796316 | 11:27,402,223 | T/A | — | uncertain significance |
| rs149603971 | 11:27,402,241 | G/C | — | uncertain significance |
| rs776464279 | 11:27,406,882 | G/A | — | likely benign |
| rs901907532 | 11:27,406,920 | G/A | — | uncertain significance |
| rs143913282 | 11:27,406,950 | C/T | — | benign |
| rs1871249 | 11:27,409,591 | T/C | regulatory region variant | — |
| rs1863276682 | 11:27,412,663 | C/G | — | uncertain significance |
| rs568680202 | 11:27,412,665 | C/G | — | uncertain significance |
| rs587777005 | 11:27,412,666 | G/A | — | association |
| rs1019972222 | 11:27,412,678 | T/G | — | uncertain significance |
| rs757351670 | 11:27,414,037 | T/C | — | pathogenic |
| rs148473042 | 11:27,414,056 | C/T | — | likely benign |
| rs58604758 | 11:27,420,145 | G/A | intron variant | — |
| rs74677637 | 11:27,427,496 | C/G | — | — |
| rs11825412 | 11:27,429,986 | C/A | — | — |
| rs368421205 | 11:27,434,416 | C/T | — | likely benign |
| rs78321654 | 11:27,453,319 | T/C | — | — |
| rs11030003 | 11:27,455,582 | C/T | regulatory region variant | — |
| rs12576419 | 11:27,460,768 | T/C | intron variant | — |
| rs2495031730 | 11:27,493,668 | G/A | — | uncertain significance |
| rs2495031908 | 11:27,493,695 | G/A | — | uncertain significance |
| rs1225161093 | 11:27,493,726 | C/G | — | uncertain significance |
| rs2495032447 | 11:27,493,762 | C/A | — | uncertain significance |
| rs2495032517 | 11:27,493,771 | G/A | — | uncertain significance |
| rs2495032688 | 11:27,493,791 | C/T | — | uncertain significance |
| rs1462232131 | 11:27,493,797 | G/A | — | uncertain significance |
| rs1461440594 | 11:27,493,801 | C/A | — | uncertain significance |
| rs531396859 | 11:27,493,803 | A/C | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.