rs78321654

This variant is located in the LGR4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

alopecia

Hagenaars SP et al. “Genetic prediction of male pattern baldness.” Plos Genetics 13(2):e1006594 (2017)

Allele A

OR —

β 0.093

p 2.0e-9

N 52,874

Large GWAS

European

About LGR4

The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]

View all LGR4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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