rs59092507

This is a upstream gene variant variant in the HPX gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in blood serum

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele G

OR 1.00

p 1.0e-13

N 466

Small GWAS

African American or Afro-Caribbean

toll-like receptor 2 measurement

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele G

OR 1.00

p 1.0e-13

N 466

Small GWAS

African American or Afro-Caribbean

About HPX

This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

View all HPX variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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