rs59211589

This is a coding sequence variant variant in the TRHDE gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

depressive symptom measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)

Allele C

OR 0.01

p 2.0e-10

N 1,067,913

Large GWAS

European

neuroticism measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)

Allele C

OR 0.01

p 2.0e-10

N 523,783

Large GWAS

European

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)

Allele C

OR 0.01

p 2.0e-10

N 2,083,151

Large GWAS

European

About TRHDE

This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]

View all TRHDE variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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