rs59499656
This is a intergenic variant variant.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body fat percentage
Martin S et al. “Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.” Diabetes 70(8):1843-1856 (2021)
Allele A
OR —
β 0.014
p 2.0e-18
N 442,278
Large GWAS
European
aspartate aminotransferase measurement, low density lipoprotein triglyceride measurement, serum alanine aminotransferase amount, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement
Martin S et al. “Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.” Diabetes 70(8):1843-1856 (2021)
Allele A
OR —
p 2.0e-13
N 389,354
Large GWAS
European
high density lipoprotein cholesterol measurement
Martin S et al. “Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.” Diabetes 70(8):1843-1856 (2021)
Allele A
OR —
β 0.013
p 5.0e-11
N 392,965
Large GWAS
European
physical activity measurement
Klimentidis YC et al. “Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.” International Journal of Obesity (2005) 42(6):1161-1176 (2018)
Allele A
OR 0.23
p 2.0e-9
N 91,084
Major Consortium StudyLarge GWAS
European
Doherty A et al. “GWAS identifies 14 loci for device-measured physical activity and sleep duration.” Nature Communications 9(1):5257 (2018)
Allele A
OR 0.03
p 2.0e-9
N 91,105
Large GWAS
European
Hanscombe KB et al. “The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare.” Genome Medicine 13(1):180 (2021)
Allele A
OR 0.21
p 5.0e-8
N 89,683
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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