rs59775462

This is a intron variant variant in the CDH6 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sleep quality

Li X et al. “Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms.” Plos Genetics 16(10):e1009089 (2020)

Allele C

OR 0.57

p 9.0e-9

N 90,515

Large GWAS

About CDH6

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

View all CDH6 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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