rs60223219
▶GWAS Catalog Trait Associations (8)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (8)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
cholesteryl esters to total lipids in small HDL percentage
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele G
OR 0.15
p 2.0e-80
N 88,329
Large GWAS
European
triglyceride measurement, depressive symptom measurement
Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)
Allele A
OR —
β 0.030
p 2.0e-34
N 15,949
Large GWAS
Hispanic or Latin American
social deprivation, triglyceride measurement
Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)
Allele A
OR 0.06
p 9.0e-30
N 15,949
Large GWAS
Hispanic or Latin American
metabolic syndrome
Ho CY et al. “A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population.” Nutrients 16(1) (2023)
Allele A
OR 0.20
p 3.0e-24
N 107,230
Large GWAS
East Asian
depressive symptom measurement, non-high density lipoprotein cholesterol measurement
Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)
Allele A
OR 0.02
p 7.0e-21
N 15,949
Large GWAS
Hispanic or Latin American
free cholesterol:total lipids ratio, blood VLDL cholesterol amount, chylomicron amount
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele A
OR 0.05
p 6.0e-14
N 111,638
Large GWAS
European
triglyceride measurement
Harshfield EL et al. “Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.” Bmc Medicine 19(1):232 (2021)
Allele C
OR 0.06
p 4.0e-11
N 5,662
Large GWAS
South Asian
free cholesterol to total lipids in chylomicrons and extremely large VLDL percentage
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele G
OR 0.05
p 1.0e-10
N 85,701
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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