rs6026740

This variant is located in the ZNF831 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

diastolic blood pressure

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele A

OR 0.52

p 7.0e-60

N 526,001

Large GWAS

European

diastolic blood pressure, alcohol drinking

Feitosa MF et al. “Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.” Plos One 13(6):e0198166 (2018)

Allele A

OR —

p 6.0e-34

N 133,351

Large GWAS

multi-ancestry

systolic blood pressure

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.03

p 2.0e-23

N 928,679

Large GWAS

multi-ancestry

mean arterial pressure, alcohol drinking

Allele A

OR —

p 4.0e-15

N 133,361

Large GWAS

multi-ancestry

mean arterial pressure, alcohol consumption quality

Allele A

OR —

p 8.0e-10

N 73,031

Large GWAS

multi-ancestry

About ZNF831

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

rs6026740

GWAS Catalog Trait Associations (5)

diastolic blood pressure

diastolic blood pressure, alcohol drinking

systolic blood pressure

mean arterial pressure, alcohol drinking

mean arterial pressure, alcohol consumption quality

About ZNF831

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