rs6040076

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pulse pressure measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.03

p 2.0e-43

N 506,308

Large GWAS

multi-ancestry

Yang ML et al. “Sex-specific genetic architecture of blood pressure.” Nature Medicine 30(3):818-828 (2024)

Allele C

OR 0.03

p 3.0e-42

N 349,328

Large GWAS

multi-ancestry

Wain LV et al. “Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.” Hypertension (dallas, Tex. : 1979) 70(3):e4-e19 (2017)

Allele C

OR 0.28

p 9.0e-18

N 150,134

Large GWAS

multi-ancestry

systolic blood pressure

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.01

p 3.0e-14

N 394,642

Large GWAS

European

birth weight

Warrington NM et al. “Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.” Nature Genetics 51(5):804-814 (2019)

Allele C

OR 0.02

p 4.0e-13

N 321,223

Large GWAS

multi-ancestry

Horikoshi M et al. “Genome-wide associations for birth weight and correlations with adult disease.” Nature 538(7624):248-252 (2016)

Allele C

OR 0.02

p 7.0e-9

N 142,558

Large GWAS

multi-ancestry

hippocampal CA3 volume

Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)

Allele C

OR 0.04

p 9.0e-9

N 38,977

Large GWAS

European, East Asian

This variant is in our database but has no known associations or PRS memberships yet.

rs6040076

GWAS Catalog Trait Associations (4)

pulse pressure measurement

systolic blood pressure

birth weight

hippocampal CA3 volume

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