rs6125826

This is a downstream gene variant variant in the RNF114 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

age at menopause

Zhang L et al. “Joint Genome-Wide Association Analyses Identified 49 Novel Loci For Age at Natural Menopause.” The Journal of Clinical Endocrinology and Metabolism 106(9):2574-2591 (2021)

Allele T

OR —

β 0.090

p 5.0e-10

N 181,219

Large GWAS

European

About RNF114

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol and plasma membrane. Biomarker of male infertility. [provided by Alliance of Genome Resources, Jul 2025]

View all RNF114 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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