rs612969

This variant is located in the TECTA gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Vertigo

Chen SP et al. “A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort.” Communications Biology 7(1):1034 (2024)
Allele G
OR 1.04
p 3.0e-12
N 1,003,399
Large GWAS
multi-ancestry
Skuladottir AT et al. “A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo.” Communications Biology 4(1):1148 (2021)
Allele G
OR 1.05
p 5.0e-11
N 942,613
Meta-analysisLarge GWAS
European
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ClinVar annotation

Benign★★★★
9 submitters3 publications

not specified; Autosomal dominant nonsyndromic hearing loss 12; Autosomal recessive nonsyndromic hearing loss 21; Nonsyndromic genetic hearing loss; not provided

View on ClinVar →

About TECTA

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]

View all TECTA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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