rs61742396

This is a protein-altering variant in the PLEKHG1 gene.

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Research that mentions this SNP (1)

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Genome-wide detection of allelic genetic variation to predict biochemical recurrence after radical prostatectomy among prostate cancer patients using an exome SNP chip
AssociationN=776Jong Jin Oh et al.(2015)· Journal of Cancer Research and Clinical Oncology

This exome array study of 776 Korean prostate cancer patients identified eight SNPs (rs77080351 OR 7.23, rs200944490 OR 5.24, rs2071292 OR 3.37, rs117237810 OR 4.86, rs191118242 OR 5.10, rs4965121 OR 2.44, rs61742396 OR 3.24, and rs6573513 OR 1.72) significantly associated with biochemical recurrence after radical prostatectomy. Adding genetic information to clinicopathological models increased predictive accuracy from 85.1% to 89.0% (P=0.025).

Traits studied:AlcoholismBreast cancerColorectal cancerGastric cancerLeukemiaLung cancerMelanomaNephroblastomaNeuroticismPancreatic carcinogenesisPanic disorderProstate cancer biochemical recurrenceRetinoblastomaSchizophrenia
PubMedDOIMetascience Observatory

About PLEKHG1

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all PLEKHG1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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