PLEKHG1

pleckstrin homology and RhoGEF domain containing G1

Summary

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants101 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs62434109	6:150,975,312	T/G	upstream gene variant	—
rs62434111	6:150,977,958	C/A	upstream gene variant	—
rs12664595	6:150,981,316	G/T	intron variant	—
rs113397083	6:150,984,741	G/A	intron variant	—
rs62434120	6:150,992,370	T/A	intron variant	—
rs17080087	6:150,997,035	T/C	intron variant	—
rs17080089	6:150,997,269	T/G	intron variant	—
rs17080091	6:150,997,401	C/T	intron variant	—
rs62434123	6:150,999,464	C/T	intron variant	—
rs62434124	6:150,999,751	C/G	—	—
rs62434125	6:151,002,371	T/C	intron variant	—
rs17080102	6:151,004,770	G/C	regulatory region variant	—
rs62434129	6:151,008,837	A/T	regulatory region variant	—
rs4869931	6:151,009,889	A/G	intron variant	—
rs9480534	6:151,015,562	A/G	intron variant	—
rs6940540	6:151,018,909	T/G	intron variant	—
rs28431130	6:151,019,072	T/G	—	—
rs76154200	6:151,019,622	A/G	regulatory region variant	—
rs1552886	6:151,019,750	A/T	—	—
rs12192990	6:151,021,978	C/G	intron variant	—
rs4869689	6:151,028,499	A/T	—	—
rs1383213719	6:151,054,830	G/A	—	uncertain significance
rs1583023760	6:151,054,837	A/C	—	uncertain significance
rs545424709	6:151,054,902	G/A	—	uncertain significance
rs2483288645	6:151,054,966	G/A	—	uncertain significance
rs199707294	6:151,055,038	C/T	—	uncertain significance
rs749448324	6:151,055,068	A/G	—	uncertain significance
rs374082085	6:151,055,106	G/A	—	uncertain significance
rs201249819	6:151,055,113	C/G	—	uncertain significance
rs200045272	6:151,055,119	C/A	—	uncertain significance
rs138156951	6:151,055,194	G/A	—	uncertain significance
rs559034455	6:151,089,795	G/A	—	uncertain significance
rs1212555079	6:151,089,858	A/G	—	uncertain significance
rs752780025	6:151,089,862	A/G	—	uncertain significance
rs75253868	6:151,102,830	T/C	—	—
rs1786298761	6:151,116,999	A/C	—	uncertain significance
rs145017897	6:151,121,859	G/A	—	uncertain significance
rs377732579	6:151,121,916	C/T	—	uncertain significance
rs10046456	6:151,125,251	G/T	intron variant	—
rs770877836	6:151,130,329	G/A	—	uncertain significance
rs1007258696	6:151,140,850	A/G	—	uncertain significance
rs146151974	6:151,144,328	G/T	upstream gene variant	—
rs1776860139	6:151,151,737	C/A	—	uncertain significance
rs376755096	6:151,151,808	A/G	—	uncertain significance
rs185585663	6:151,151,811	G/A	—	uncertain significance
rs200746163	6:151,151,869	C/T	—	uncertain significance
rs2483791811	6:151,151,872	T/G	—	uncertain significance
rs541211219	6:151,152,077	C/A	—	uncertain significance
rs752804721	6:151,152,171	G/A	—	uncertain significance
rs1776895288	6:151,152,195	A/G	—	likely benign
rs143818607	6:151,152,230	T/C	—	likely benign
rs759304114	6:151,152,274	G/A	—	uncertain significance
rs372612259	6:151,152,321	C/T	—	uncertain significance
rs376749138	6:151,152,322	G/A	—	uncertain significance
rs143400573	6:151,152,382	C/G	—	uncertain significance
rs201032405	6:151,152,395	A/C	—	uncertain significance
rs140318446	6:151,152,397	C/T	—	uncertain significance
rs1776912574	6:151,152,421	A/G	—	uncertain significance
rs1281457415	6:151,152,538	A/G	—	uncertain significance
rs193920959	6:151,152,540	C/T	—	uncertain significance
rs772089894	6:151,152,541	G/A	—	uncertain significance
rs759847501	6:151,152,561	G/A	—	uncertain significance
rs777837004	6:151,152,633	G/A	—	uncertain significance
rs771072416	6:151,152,640	C/T	—	uncertain significance
rs776868858	6:151,152,642	T/A	—	uncertain significance
rs140522547	6:151,152,646	A/T	—	uncertain significance
rs146164013	6:151,152,813	C/A	—	uncertain significance
rs141171823	6:151,152,838	G/T	—	uncertain significance
rs1165973892	6:151,152,932	G/C	—	uncertain significance
rs2483807444	6:151,152,972	A/G	—	uncertain significance
rs1337488394	6:151,152,988	A/G	—	uncertain significance
rs2483808389	6:151,153,038	C/T	—	uncertain significance
rs922372297	6:151,153,043	C/A	—	uncertain significance
rs779851602	6:151,153,045	G/A	—	uncertain significance
rs148507761	6:151,153,188	C/T	—	uncertain significance
rs113595784	6:151,153,189	G/A	—	uncertain significance
rs1776976443	6:151,153,251	G/A	—	uncertain significance
rs1275022966	6:151,153,307	C/G	—	uncertain significance
rs780771753	6:151,153,318	A/G	—	uncertain significance
rs150224269	6:151,153,338	A/G	—	uncertain significance
rs147602424	6:151,160,975	G/A	—	uncertain significance
rs146130174	6:151,161,053	C/T	—	uncertain significance
rs200501160	6:151,161,089	C/T	—	uncertain significance
rs61742396	6:151,161,116	G/A	missense variant	—
rs777126277	6:151,161,157	G/A	—	uncertain significance
rs139978019	6:151,161,206	C/T	—	uncertain significance
rs368267200	6:151,161,223	A/G	—	uncertain significance
rs2483878501	6:151,161,316	G/C	—	uncertain significance
rs2483879203	6:151,161,374	G/T	—	uncertain significance
rs1017719233	6:151,161,376	C/T	—	uncertain significance
rs144678547	6:151,161,383	G/T	—	uncertain significance
rs780208275	6:151,161,451	A/G	—	uncertain significance
rs772613294	6:151,161,500	C/G	—	uncertain significance
rs2483880506	6:151,161,540	G/C	—	uncertain significance
rs772973070	6:151,161,691	A/G	—	uncertain significance
rs765508188	6:151,161,733	G/A	—	uncertain significance
rs568812470	6:151,161,766	C/T	—	uncertain significance
rs1014853275	6:151,161,865	A/C	—	uncertain significance
rs182466876	6:151,161,872	C/T	—	uncertain significance
rs1309087413	6:151,162,023	C/G	—	uncertain significance

Showing 100 of 101 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.