rs61990288
This is a regulatory region variant variant in the LRFN5 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
major depressive disorder
Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)
Allele G
OR 1.03
p 2.0e-31
N 807,553
Meta-analysisLarge GWAS
European
Meng X et al. “Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.” Nature Genetics 56(2):222-233 (2024)
Allele G
OR 0.03
p 6.0e-18
N 1,820,689
Large GWAS
multi-ancestry
bipolar disorder, major depressive disorder
Coleman JRI et al. “The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.” Biological Psychiatry 88(2):169-184 (2020)
Allele G
OR 1.03
p 2.0e-10
N 625,026
Large GWAS
European
About LRFN5
This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [provided by RefSeq, Sep 2016]
View all LRFN5 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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