rs62053943
This is a intron variant variant in the LINC02210-CRHR1 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Parkinson disease
Kim JJ et al. “Multi-ancestry genome-wide association meta-analysis of Parkinson's disease.” Nature Genetics 56(1):27-36 (2024)
Allele T
OR —
p 1.0e-69
N 2,525,730
Meta-analysisLarge GWAS
multi-ancestry
Nalls MA et al. “Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.” The Lancet. Neurology 18(12):1091-1102 (2019)
Allele T
OR 0.27
p 4.0e-68
N 482,730
Meta-analysisLarge GWAS
European
Bandres-Ciga S et al. “The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight.” Movement Disorders : Official Journal of the Movement Disorder Society 34(12):1851-1863 (2019)
Allele T
OR 0.30
p 8.0e-9
N 7,588
Large GWAS
European
neuroticism measurement
Hill WD et al. “Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.” Molecular Psychiatry 25(11):3034-3052 (2020)
Allele C
OR 0.01
p 4.0e-14
N 270,059
Large GWAS
European
BMI-adjusted waist circumference
Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele T
OR 0.03
p 1.0e-10
N 219,872
Major Consortium StudyLarge GWAS
European
cortical thickness
Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)
Allele T
OR —
p 5.0e-9
N 34,554
Large GWAS
European
About LINC02210-CRHR1
This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]
View all LINC02210-CRHR1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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