rs621554
This is a intron variant variant in the DLC1 gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Association ofPSCArs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer diseaseAssociationN=1,747María Asunción García-González et al.(2015)· International Journal of Cancer
A case-control study of 1,115 gastric cancer (GCa) cases and 1,172 controls from Eastern China examined whether 42 common genetic variants associated with GCa susceptibility predict patient prognosis. A weighted genetic risk score (GRS) was constructed and tested in 633 GCa cases using Cox proportional hazards regression. The results found no significant association between increasing GRS and risk of death (low vs medium: HR=0.87, P=0.349; high vs medium: HR=0.97, P=0.847), and GRS did not improve prognostic prediction beyond clinical factors alone (C-index 0.78 vs 0.78, P=0.986). Genetic variants associated with gastric cancer susceptibility do not appear to predict worse prognosis in Chinese gastric cancer patients.
About DLC1
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
View all DLC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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