DLC1

DLC1 Rho GTPase activating protein

Summary

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

Known Variants406 total

rsidPosition (GRCh37)AllelesClassClinVar
rs3702308128:12,943,310G/C—likely benign
rs13193994018:12,943,324C/T—uncertain significance
rs7596266318:12,943,325T/A—uncertain significance
rs12621847188:12,943,327G/A—uncertain significance
rs1440900288:12,943,365G/A—likely benign
rs3730604848:12,943,370C/T—conflicting classifications of pathogenicity
rs1422531038:12,943,382C/T—benign
rs18175145218:12,943,394C/A—uncertain significance
rs25369194108:12,943,402T/C—uncertain significance
rs3756631528:12,943,417G/A—uncertain significance
rs25369196388:12,943,419G/A—likely benign
rs614309198:12,943,625C/G—benign
rs6215548:12,943,691C/Tintron variantbenign
rs14565706348:12,943,789C/G—likely benign
rs9239652638:12,943,790A/G—likely benign
rs3746612438:12,943,791G/C—likely benign
rs1997838558:12,943,795A/T—conflicting classifications of pathogenicity
rs25369249948:12,943,816C/A—uncertain significance
rs10647957458:12,943,851G/A—uncertain significance
rs2009937638:12,943,855A/C—conflicting classifications of pathogenicity
rs3676797468:12,943,905C/T—uncertain significance
rs7778326668:12,943,914G/C—uncertain significance
rs11738603888:12,943,951G/A—likely benign
rs7613888248:12,943,972T/C—conflicting classifications of pathogenicity
rs12974789128:12,943,975G/A—uncertain significance
rs12988345868:12,943,982C/G—likely benign
rs6949688:12,945,852G/A—benign
rs7525885848:12,945,989C/T—likely benign
rs12824439708:12,945,993C/T—uncertain significance
rs7792573558:12,946,006C/T—uncertain significance
rs3771276528:12,946,014C/T—uncertain significance
rs7604408078:12,946,081C/T—uncertain significance
rs12175266048:12,946,083A/G—uncertain significance
rs1398512878:12,946,100C/A—likely benign
rs25369473798:12,946,128T/A—uncertain significance
rs1496706778:12,946,133T/C—likely benign
rs7567156848:12,946,137C/T—uncertain significance
rs25369476708:12,946,153C/T—uncertain significance
rs7683610398:12,946,158A/G—uncertain significance
rs7765943678:12,946,164G/A—uncertain significance
rs1932063798:12,946,208G/A—benign
rs735523608:12,946,292A/G—benign
rs1508348468:12,947,773C/T—benign
rs1392513118:12,947,789G/C—uncertain significance
rs7789723878:12,947,810C/G—uncertain significance
rs14422721218:12,947,816A/C—uncertain significance
rs11826768468:12,947,829C/G—uncertain significance
rs617520258:12,947,856C/A—benign
rs25369644648:12,947,858T/C—uncertain significance
rs7786900408:12,947,867T/A—likely benign
rs2018861468:12,947,875G/T—uncertain significance
rs18179485168:12,947,884G/T—uncertain significance
rs1460942428:12,947,888T/C—uncertain significance
rs7603254648:12,947,919T/C—uncertain significance
rs2001182478:12,947,932C/A—conflicting classifications of pathogenicity
rs3694411188:12,947,954C/T—uncertain significance
rs7750334748:12,947,976G/A—uncertain significance
rs2001022328:12,947,985C/T—likely benign
rs5698137408:12,947,987G/A—likely benign
rs735523668:12,948,105C/A—benign
rs5950038:12,948,136T/G—benign
rs732066958:12,948,613A/G—benign
rs7541322568:12,948,835G/T—uncertain significance
rs7462952508:12,948,848G/A—likely benign
rs7804698718:12,948,850C/T—uncertain significance
rs7692112478:12,948,861G/T—uncertain significance
rs5687962968:12,948,863C/T—likely benign
rs7593925118:12,948,879G/A—uncertain significance
rs7475027698:12,948,907C/G—uncertain significance
rs7754557138:12,948,939A/T—uncertain significance
rs1381810488:12,948,940C/T—uncertain significance
rs1495606108:12,948,941C/T—uncertain significance
rs6090208:12,948,951A/G—benign
rs5555863228:12,948,959A/G—likely benign
rs3742165908:12,948,961G/C—likely benign
rs735523728:12,949,009A/C—benign
rs3721332958:12,950,105C/A—uncertain significance
rs2014193478:12,950,109T/C—benign
rs78295358:12,950,110A/G—benign
rs25369901958:12,950,124G/A—uncertain significance
rs7622996478:12,950,146G/C—uncertain significance
rs1446447638:12,950,171C/T—likely benign
rs7678957318:12,950,174T/G—uncertain significance
rs3702070658:12,950,218C/T—uncertain significance
rs9374800578:12,950,244T/C—uncertain significance
rs1459897308:12,950,252G/T—likely benign
rs25369932108:12,950,272T/C—uncertain significance
rs12312382288:12,950,288C/G—uncertain significance
rs1460511428:12,950,310T/A—likely benign
rs5681828:12,950,315T/G—benign
rs1164504698:12,950,333A/G—benign
rs7535143678:12,950,337G/A—uncertain significance
rs1420247728:12,950,351C/A—benign
rs773094888:12,950,486C/T—benign
rs9656728:12,952,116A/G—benign
rs6589488:12,952,230T/C—benign
rs7552272688:12,952,276A/G—uncertain significance
rs6588568:12,952,293C/T—benign
rs352794478:12,952,305C/T—likely benign
rs3768355848:12,952,349T/C—uncertain significance

Showing 100 of 406 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.