rs62621197

This variant is located in the ADAMTS10 gene.

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GWAS Catalog Trait Associations (23)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height, body weights and measures

Galván-Femenía I et al. “Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort.” Journal of Medical Genetics 55(11):765-778 (2018)
Allele T
OR 0.11
p 5.0e-121
N 4,988
Large GWAS
European

health trait

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.06
p 1.0e-108
N 405,979
Large GWAS
European

forced expiratory volume

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.06
p 2.0e-40
N 373,397
Large GWAS
European

Abnormality of the skeletal system

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.04
p 9.0e-28
N 394,642
Large GWAS
European

base metabolic rate measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.03
p 2.0e-21
N 394,642
Large GWAS
European

fat pad mass

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.05
p 7.0e-21
N 394,642
Large GWAS
European

carpal tunnel syndrome

Skuladottir AT et al. “A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome.” Nature Communications 13(1):1598 (2022)
Allele T
OR 1.20
p 7.0e-20
N 1,239,680
Meta-analysisLarge GWAS
European
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.23
p 4.0e-12
N 658,927
Large GWAS
multi-ancestry
Wiberg A et al. “A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.” Nature Communications 10(1):1030 (2019)
Allele T
OR 1.31
p 8.0e-14
N 401,656
Large GWAS
European

whole body water mass

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.03
p 9.0e-20
N 394,642
Large GWAS
European

lean body mass

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele T
OR 0.03
p 3.0e-18
N 337,739
Large GWAS
European

appendicular lean mass

Pei YF et al. “The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.” Communications Biology 3(1):608 (2020)
Allele T
OR 0.04
p 1.0e-17
N 450,243
Major Consortium StudyLarge GWAS
European
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ClinVar annotation

Benign★★★☆
8 submitters2 publications

Weill-Marchesani syndrome; not provided; not specified; Colon adenocarcinoma; Acute myeloid leukemia; Hepatocellular carcinoma; Adrenocortical carcinoma, hereditary; Malignant lymphoma, large B-cell, diffuse; Thymoma

View on ClinVar →

About ADAMTS10

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

View all ADAMTS10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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