rs6485702

This variant is located in the LRP4 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heel bone mineral density

Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)

Allele T

OR 0.03

p 3.0e-63

N 426,824

Large GWAS

European

cortical thickness

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)

Allele T

OR 6.52

p 7.0e-11

N 33,748

Large GWAS

European

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ClinVar annotation

Benign★★★☆

9 submitters2 publications

Cenani-Lenz syndactyly syndrome; not specified; Congenital myasthenic syndrome 17;Sclerosteosis 2;Cenani-Lenz syndactyly syndrome; not provided; Sclerosteosis 2; Congenital myasthenic syndrome 17

View on ClinVar →

About LRP4

This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]

View all LRP4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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