rs6490177
This is a intron variant variant in the TAOK3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neuroticism measurement
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.54
p 6.0e-11
N 380,506
Large GWAS
European
Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 6.05
p 1.0e-9
N 449,484
Meta-analysisLarge GWAS
European
Nagel M et al. “Genome-wide association study of the sensitivity to environmental stress and adversity neuroticism cluster.” Acta Psychiatrica Scandinavica 141(5):476-478 (2020)
Allele A
OR —
β 0.019
p 1.0e-9
N 351,827
Large GWAS
European
About TAOK3
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
View all TAOK3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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