rs6495046

This is a intron variant variant in the NEO1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

dental caries, dentures

Shungin D et al. “Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.” Nature Communications 10(1):2773 (2019)
Allele C
OR 0.02
p 3.0e-10
N 487,823
Large GWAS
multi-ancestry

dentures

Shungin D et al. “Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.” Nature Communications 10(1):2773 (2019)
Allele C
OR 0.03
p 9.0e-9
N 461,031
Large GWAS
European

About NEO1

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

View all NEO1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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