NEO1

neogenin 1

Summary

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Known Variants112 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs748943546	15:73,345,060	C/A	—	uncertain significance
rs2542684864	15:73,345,069	T/C	—	uncertain significance
rs773350771	15:73,345,119	A/T	—	uncertain significance
rs6495046	15:73,353,175	C/G	intron variant	—
rs10468056	15:73,377,122	T/G	intron variant	—
rs8026121	15:73,381,240	G/A	intron variant	—
rs139882931	15:73,409,014	A/G	—	likely benign
rs2071340681	15:73,409,025	T/C	—	uncertain significance
rs143764154	15:73,409,045	G/A	—	uncertain significance
rs561097866	15:73,409,109	A/G	—	uncertain significance
rs8037213	15:73,413,070	G/C	intron variant	—
rs2543662975	15:73,414,874	A/G	—	uncertain significance
rs144328581	15:73,414,888	A/G	—	benign
rs142340038	15:73,414,920	A/G	—	likely benign
rs146427236	15:73,414,959	C/T	—	likely benign
rs756634630	15:73,415,030	A/T	—	uncertain significance
rs148761830	15:73,415,080	C/T	—	benign
rs142363521	15:73,415,081	G/A	—	likely benign
rs369381005	15:73,415,123	G/A	—	uncertain significance
rs539606269	15:73,418,752	T/G	—	likely benign
rs780801893	15:73,418,770	T/A	—	uncertain significance
rs745561049	15:73,418,780	G/C	—	uncertain significance
rs369836149	15:73,418,884	A/G	—	uncertain significance
rs8035499	15:73,428,224	T/A	—	benign
rs201019764	15:73,428,260	G/A	—	uncertain significance
rs145921136	15:73,428,264	G/T	—	uncertain significance
rs72741418	15:73,428,374	T/C	—	likely benign
rs112752532	15:73,431,021	T/A	—	—
rs34386426	15:73,433,128	G/A	downstream gene variant	—
rs8039418	15:73,441,432	T/G	—	—
rs983067	15:73,447,920	T/C	intron variant	—
rs541189631	15:73,461,053	C/G	—	—
rs2548536807	15:73,468,780	A/T	—	uncertain significance
rs2548537000	15:73,468,842	G/A	—	uncertain significance
rs142917180	15:73,470,657	A/G	—	uncertain significance
rs748463451	15:73,470,678	G/T	—	uncertain significance
rs2035403005	15:73,470,759	C/T	—	uncertain significance
rs76944250	15:73,470,777	G/T	—	benign
rs11072405	15:73,485,160	A/T	—	—
rs1812835	15:73,507,504	C/A	intron variant	—
rs367684014	15:73,528,700	C/T	—	uncertain significance
rs760526840	15:73,528,734	G/A	—	likely benign
rs751967941	15:73,528,777	A/G	—	uncertain significance
rs75740781	15:73,528,797	C/T	—	benign
rs778240415	15:73,528,807	C/G	—	uncertain significance
rs3743488	15:73,536,691	T/C	—	benign
rs200297567	15:73,536,755	G/T	—	uncertain significance
rs547304759	15:73,541,446	C/T	—	uncertain significance
rs1329065831	15:73,541,451	A/G	—	uncertain significance
rs376506948	15:73,541,467	C/G	—	uncertain significance
rs201806496	15:73,541,491	A/G	—	uncertain significance
rs3736510	15:73,541,513	A/G	—	benign
rs1567599442	15:73,541,934	T/C	—	uncertain significance
rs865811401	15:73,542,011	C/T	—	uncertain significance
rs368526754	15:73,542,048	G/A	—	uncertain significance
rs2623989	15:73,545,732	T/C	—	benign
rs2548855196	15:73,547,063	A/G	—	uncertain significance
rs1197357686	15:73,547,087	A/G	—	uncertain significance
rs757256214	15:73,547,093	G/A	—	uncertain significance
rs757127056	15:73,547,099	G/A	—	uncertain significance
rs2040255477	15:73,547,110	C/G	—	uncertain significance
rs999871472	15:73,547,143	G/A	—	uncertain significance
rs1018069783	15:73,547,153	T/C	—	uncertain significance
rs1463014616	15:73,547,176	C/A	—	likely benign
rs150158027	15:73,547,178	A/G	—	likely benign
rs369991249	15:73,551,157	A/G	—	uncertain significance
rs141602999	15:73,551,170	C/T	—	uncertain significance
rs952837071	15:73,551,172	G/C	—	uncertain significance
rs140293397	15:73,552,659	G/A	—	uncertain significance
rs2548876229	15:73,552,677	A/G	—	uncertain significance
rs764902411	15:73,552,765	A/T	—	uncertain significance
rs145923699	15:73,558,701	G/A	—	uncertain significance
rs746900765	15:73,562,492	T/C	—	uncertain significance
rs2680348	15:73,562,532	C/T	—	benign
rs768773856	15:73,562,729	A/C	—	uncertain significance
rs1250227209	15:73,562,745	G/A	—	uncertain significance
rs148148823	15:73,564,825	G/A	—	likely benign
rs2548921303	15:73,564,850	A/G	—	likely benign
rs483352721	15:73,564,873	C/G	—	uncertain significance
rs1131854	15:73,564,881	T/C	—	benign
rs3784795	15:73,565,157	A/T	intron variant	—
rs140996696	15:73,566,160	A/C	—	uncertain significance
rs2548928768	15:73,566,224	A/G	—	uncertain significance
rs201250356	15:73,566,314	T/A	—	uncertain significance
rs569350195	15:73,567,033	C/T	—	uncertain significance
rs771256568	15:73,575,314	G/A	—	uncertain significance
rs551596506	15:73,575,321	T/G	—	likely benign
rs141535724	15:73,575,412	G/T	—	uncertain significance
rs145236568	15:73,575,428	G/A	—	uncertain significance
rs368178634	15:73,580,659	G/A	—	uncertain significance
rs762671370	15:73,580,688	C/T	—	uncertain significance
rs755241463	15:73,580,767	T/C	—	uncertain significance
rs1398603591	15:73,580,804	T/G	—	uncertain significance
rs367758397	15:73,580,821	A/G	—	uncertain significance
rs138782904	15:73,580,853	A/T	—	uncertain significance
rs2042034658	15:73,580,854	T/C	—	uncertain significance
rs2548997088	15:73,581,519	G/T	—	uncertain significance
rs1352404400	15:73,581,553	T/C	—	uncertain significance
rs137965291	15:73,581,555	C/G	—	uncertain significance
rs546550682	15:73,581,556	C/G	—	uncertain significance

Showing 100 of 112 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.