rs6510997
This variant is located in the CRTC1 gene.
▶Research that mentions this SNP (1)
▶Influence ofCRTC1Polymorphisms on Body Mass Index and Fat Mass in Psychiatric Patients and the General Adult PopulationAssociationN=129,000Choong E. et al.(2013)· JAMA Psychiatry
This study examined CRTC1 polymorphisms and their association with body mass index (BMI) and fat mass in psychiatric patients and the general population. The rs3746266A>G variant was significantly associated with lower BMI in psychiatric patients (beta ≈ 1.81-3.87 kg/m², p<0.0001), with the strongest effect in women younger than 45 years. The proxy SNP rs6510997C>T showed associations with fat mass in a large population-based cohort (n=123,865, p=0.01).
About CRTC1
Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all CRTC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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