rs6674596
This is a intron variant variant in the FMO1 gene.
▶Research that mentions this SNP (1)
▶Targeted sequencing identifies genetic polymorphisms of flavin‐containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African AmericanAssociationN=2,820Tian‐Xiao Zhang et al.(2017)· Brain and Behavior
A targeted sequencing study of 2,820 subjects (1,583 cases, 1,237 controls) investigating FMO gene polymorphisms in nicotine dependence. Identified ethnicity-specific associations: in European Americans, rs6674596 in FMO1 showed strongest association (p=0.0004, OR=0.67), while rs6608453 in FMO6P was most significant in African Americans (p=0.001, OR=0.64). Most significant variants were intronic with unclear functional significance, and no associations were detected for rare variants.
About FMO1
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
View all FMO1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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