rs6682925

A prospective study of 568 Chinese non-small-cell lung cancer (NSCLC) patients found that four immune gene polymorphisms were independently associated with survival: IL-5R rs11713419 (5'-UTR, P=0.001), IL23R rs6682925 (5'-FR, P=0.017), TLR1 rs5743551 (5'-FR, P=0.02), and TLR3 rs3775291 (Leu412Phe, P=0.01). Patients carrying 1 unfavorable locus had 124% increased mortality risk (HR=2.24, 95% CI: 1.33-3.75), and those with 2-4 unfavorable loci had 175% increased risk (HR=2.75, 95% CI: 1.67-4.51). Combined SNP and clinical risk score model achieved 5-year AUC of 0.831 versus 0.484 for clinical factors alone.

A case-control study of 1,645 esophageal cancer cases and 1,694 controls in a Chinese population found that IL-23R rs6682925 T>C (adjusted OR=1.23, 95% CI 1.07-1.42) and rs1884444 T>G (adjusted OR=1.16, 95% CI 1.01-1.33) variant genotypes were significantly associated with increased esophageal cancer risk. The associations were independent of smoking and alcohol drinking status.