rs6740847

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (11)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

monocyte count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.21

p 9.9e-324

N 259,608

Major Consortium StudyLarge GWAS

European

neutrophil count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR 0.02

p 4.0e-29

N 519,288

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.03

p 5.0e-12

N 170,702

Large GWAS

European

myeloid leukocyte count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.04

p 1.0e-27

N 169,219

Large GWAS

European

leukocyte quantity

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.04

p 4.0e-25

N 172,435

Large GWAS

European

inflammatory bowel disease

de Lange KM et al. “Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.” Nature Genetics 49(2):256-261 (2017)

Allele A

OR 1.10

p 1.0e-13

N 59,957

Large GWAS

NR, European

immature granulocyte count

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele G

OR 0.05

p 5.0e-13

N 37,939

Large GWAS

European

neutrophil count, eosinophil count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.03

p 9.0e-13

N 170,384

Large GWAS

European

granulocyte count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.03

p 1.0e-12

N 169,822

Large GWAS

European

neutrophil count, basophil count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.03

p 5.0e-12

N 170,143

Large GWAS

European

vascular cell adhesion protein 1 amount

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele A

OR 0.10

p 1.0e-11

N 10,708

Large GWAS

European

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Research that mentions this SNP (1)

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LPAR1andITGA4regulate peripheral blood monocyte counts

AssociationN=5,347Narelle Maugeri et al.(2011)· Human Mutation

A GWAS follow-up study identifies LPAR1 and ITGA4 as causal genes regulating peripheral blood monocyte counts. rs7023923 (chromosome 9q31) significantly associates with increased LPAR1 expression (P = 9.5 × 10⁻⁶) and monocyte counts, while rs6740847 (chromosome 2q31) associates with decreased ITGA4 expression and increased monocyte counts (combined P = 2.7 × 10⁻¹⁰). These two variants jointly account for 1.2% of variation in monocyte numbers.

Traits studied:Monocyte countsPeripheral blood monocyte numbers

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs6740847

GWAS Catalog Trait Associations (11)

monocyte count

neutrophil count

myeloid leukocyte count

leukocyte quantity

inflammatory bowel disease

immature granulocyte count

neutrophil count, eosinophil count

granulocyte count

neutrophil count, basophil count

vascular cell adhesion protein 1 amount

Research that mentions this SNP (1)

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