rs6743376

This is a protein-altering variant in the IL1F10 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

C-reactive protein measurement

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele A

OR 0.02

p 4.0e-30

N 575,531

Large GWAS

European

interleukin 1 receptor antagonist measurement

Matteini AM et al. “Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.” Cytokine 65(1):10-6 (2014)

Allele A

OR 0.13

p 2.0e-26

N 4,443

Large GWAS

European

About IL1F10

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

View all IL1F10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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