rs6747972

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

movement disorder

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.09
p 1.0e-21
N 611,205
Major Consortium StudyLarge GWAS
multi-ancestry

restless legs syndrome

Winkelmann J et al. “Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.” Plos Genetics 7(7):e1002171 (2011)
Allele A
OR 1.23
p 9.0e-11
N 2,448
Large GWAS
European
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Research that mentions this SNP (1)

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Association of genetic variants in migraineurs with and without restless legs syndrome
AssociationN=233Guan‐Yu Lin et al.(2020)· Annals of Clinical and Translational Neurology

Association study of 233 Taiwanese migraineurs examining SNP variants related to restless legs syndrome (RLS) comorbidity. Two SNPs reached genome-wide significance: rs77234324 in LGR6 (OR=8.978, P=2.57E-07) and rs79004933 in an intergenic region (OR=5.281, P=3.03E-07) were associated with RLS in migraineurs. Five additional SNPs (including rs4243475 in UTRN) were associated with RLS specifically in migraine without aura patients.

Traits studied:Chronic migraineEpisodic migraineMigraine with auraMigraine without auraRestless legs syndrome
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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