Trait
SNPs associated with Restless Legs Syndrome
356 genetic variants across 64 genes have been associated with Restless Legs Syndrome in published research. Key genes include ADGRB3, ASTN2, ATRNL1.
Associated variants356 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs868036 | MAP2K5 | GWAS association (p=9.0e-288) | Meta-analysis |
| rs61192259 | BTBD9 | GWAS association (p=4.0e-202) | Meta-analysis |
| rs45544231 | CASC16 | GWAS association (p=7.0e-133) | Meta-analysis |
| rs111652004 | — | GWAS association (p=3.0e-73) | Meta-analysis |
| rs996064 | — | GWAS association (p=1.0e-69) | Meta-analysis |
| rs12046503 | — | GWAS association (p=3.0e-63) | Meta-analysis |
| rs1820989 | — | GWAS association (p=1.0e-58) | Meta-analysis |
| rs365032 | — | GWAS association (p=5.0e-52) | Meta-analysis |
| rs340561 | — | GWAS association (p=3.0e-43) | Meta-analysis |
| rs1836229 | — | GWAS association (p=7.0e-42) | Meta-analysis |
| rs12450895 | — | GWAS association (p=4.0e-40) | Meta-analysis |
| rs35987657 | LOC105374107 | GWAS association (p=4.0e-38) | Meta-analysis |
| rs10208712 | — | GWAS association (p=1.0e-34) | Meta-analysis |
| rs10952927 | LOC107986816 | GWAS association (p=2.0e-34) | Meta-analysis |
| rs17636328 | — | GWAS association (p=3.0e-26) | Meta-analysis |
| rs80319144 | CCDC148 | GWAS association (p=3.0e-25) | Meta-analysis |
| rs1848460 | — | GWAS association (p=3.0e-15) | Meta-analysis |
| rs62535767 | — | GWAS association (p=5.0e-14) | Meta-analysis |
| rs113851554 | — | GWAS association (p=0.0e+00) | Meta-analysis |
| rs537670230 | — | GWAS association (p=2.0e-69) | Major Consortium Study |
| rs11815777 | — | GWAS association (p=2.0e-58) | Major Consortium Study |
| rs10116689 | PTPRD | GWAS association (p=1.0e-31) | Major Consortium Study |
| rs3104767 | CASC16 | GWAS association (p=6.0e-31) | Major Consortium Study |
| rs4776967 | — | GWAS association (p=2.0e-30) | Major Consortium Study |
| rs500151 | — | GWAS association (p=1.0e-27) | Major Consortium Study |
| rs4603157 | — | GWAS association (p=3.0e-27) | Major Consortium Study |
| rs145834406 | CCDC148 | GWAS association (p=3.0e-25) | Major Consortium Study |
| rs7102266 | — | GWAS association (p=2.0e-17) | Major Consortium Study |
| rs1908245 | — | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs6265 | BDNF | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs6920488 | — | GWAS association (p=4.0e-93) | Major Consortium Study |
| rs6776484 | — | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs11980428 | LOC107986816 | GWAS association (p=1.0e-23) | Major Consortium Study |
| rs3112626 | CASC16 | GWAS association (p=0.0e+00) | Large GWAS |
| rs10947738 | — | GWAS association (p=0.0e+00) | Large GWAS |
| rs3104769 | CASC16 | GWAS association (p=9.0e-275) | Large GWAS |
| rs4714163 | BTBD9 | GWAS association (p=2.0e-220) | Large GWAS |
| rs12044119 | — | GWAS association (p=1.0e-164) | Large GWAS |
| rs34602324 | — | GWAS association (p=5.0e-162) | Large GWAS |
| rs77276698 | CCDC148 | GWAS association (p=1.0e-115) | Large GWAS |
| rs10769894 | — | GWAS association (p=5.0e-115) | Large GWAS |
| rs442083 | — | GWAS association (p=2.0e-114) | Large GWAS |
| rs7779363 | LOC107986816 | GWAS association (p=1.0e-110) | Large GWAS |
| rs6477358 | PTPRD | GWAS association (p=9.0e-110) | Large GWAS |
| rs10458531 | — | GWAS association (p=1.0e-104) | Large GWAS |
| rs5932706 | — | GWAS association (p=3.0e-91) | Large GWAS |
| rs113330028 | CCDC148 | GWAS association (p=7.0e-89) | Large GWAS |
| rs6439256 | — | GWAS association (p=3.0e-80) | Large GWAS |
| rs1389581 | — | GWAS association (p=1.0e-78) | Large GWAS |
| rs7620647 | — | GWAS association (p=8.0e-69) | Large GWAS |
| rs4596705 | — | GWAS association (p=3.0e-68) | Large GWAS |
| rs78593025 | TOX3 | GWAS association (p=2.0e-66) | Large GWAS |
| rs6465150 | LOC107986816 | GWAS association (p=1.0e-63) | Large GWAS |
| rs9859139 | LOC105374107 | GWAS association (p=3.0e-60) | Large GWAS |
| rs9369006 | — | GWAS association (p=7.0e-60) | Large GWAS |
| rs868037 | — | GWAS association (p=2.0e-56) | Large GWAS |
| rs10757843 | — | GWAS association (p=1.0e-54) | Large GWAS |
| rs7532780 | — | GWAS association (p=2.0e-54) | Large GWAS |
| rs3104797 | — | GWAS association (p=4.0e-51) | Large GWAS |
| rs10816068 | — | GWAS association (p=4.0e-51) | Large GWAS |
| rs2300478 | MEIS1 | GWAS association (p=3.0e-28) | Large GWAS |
| rs4369536 | — | GWAS association (p=6.0e-48) | Large GWAS |
| rs17303114 | — | GWAS association (p=7.0e-48) | Large GWAS |
| rs10758996 | PTPRD | GWAS association (p=3.0e-47) | Large GWAS |
| rs708023 | — | GWAS association (p=1.0e-44) | Large GWAS |
| rs8037262 | — | GWAS association (p=9.0e-43) | Large GWAS |
| rs62562210 | ASTN2 | GWAS association (p=9.0e-43) | Large GWAS |
| rs12637600 | — | GWAS association (p=1.0e-42) | Large GWAS |
| rs11602686 | — | GWAS association (p=2.0e-40) | Large GWAS |
| rs72718216 | — | GWAS association (p=4.0e-39) | Large GWAS |
| rs11974909 | — | GWAS association (p=8.0e-39) | Large GWAS |
| rs1334011 | — | GWAS association (p=3.0e-38) | Large GWAS |
| rs77588655 | — | GWAS association (p=2.0e-36) | Large GWAS |
| rs28871269 | — | GWAS association (p=8.0e-36) | Large GWAS |
| rs3813996 | DAB1 | GWAS association (p=2.0e-31) | Large GWAS |
| rs9530283 | — | GWAS association (p=6.0e-30) | Large GWAS |
| rs9529984 | — | GWAS association (p=1.0e-29) | Large GWAS |
| rs10193366 | — | GWAS association (p=2.0e-29) | Large GWAS |
| rs2368671 | CITED1 | GWAS association (p=2.0e-29) | Large GWAS |
| rs607289 | — | GWAS association (p=3.0e-28) | Large GWAS |
| rs3923809 | BTBD9 | GWAS association (p=1.0e-17) | Large GWAS |
| rs28693620 | — | GWAS association (p=4.0e-27) | Large GWAS |
| rs11148275 | — | GWAS association (p=6.0e-27) | Large GWAS |
| rs9536410 | — | GWAS association (p=7.0e-26) | Large GWAS |
| rs10895816 | LOC105369468 | GWAS association (p=5.0e-25) | Large GWAS |
| rs192695785 | — | GWAS association (p=6.0e-25) | Large GWAS |
| rs77641763 | — | GWAS association (p=2.0e-24) | Large GWAS |
| rs730635 | — | GWAS association (p=3.0e-24) | Large GWAS |
| rs10163708 | — | GWAS association (p=4.0e-23) | Large GWAS |
| rs8074498 | — | GWAS association (p=5.0e-23) | Large GWAS |
| rs12593813 | MAP2K5 | GWAS association (p=1.0e-15) | Large GWAS |
| rs4844850 | LOC105372898 | GWAS association (p=1.0e-22) | Large GWAS |
| rs9357271 | BTBD9 | GWAS association (p=8.0e-22) | Large GWAS |
| rs56970792 | — | GWAS association (p=8.0e-22) | Large GWAS |
| rs3820576 | DAB1 | GWAS association (p=1.0e-21) | Large GWAS |
| rs199997012 | CCDC148 | GWAS association (p=1.0e-21) | Large GWAS |
| rs512255 | — | GWAS association (p=2.0e-21) | Large GWAS |
| rs35196838 | — | GWAS association (p=7.0e-21) | Large GWAS |
| rs1468270 | — | GWAS association (p=1.0e-20) | Large GWAS |
| rs7028516 | — | GWAS association (p=1.0e-20) | Large GWAS |
Showing the top 100 of 356 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.