DAB1

DAB adaptor protein 1

Summary

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]

Known Variants136 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs112694934	1:57,466,009	G/T	—	—
rs114941053	1:57,476,376	C/T	—	uncertain significance
rs141647150	1:57,476,377	G/A	—	likely benign
rs1383010081	1:57,476,415	T/C	—	uncertain significance
rs755457249	1:57,476,426	A/G	—	uncertain significance
rs779432585	1:57,476,430	G/C	—	uncertain significance
rs748863712	1:57,476,868	T/C	—	uncertain significance
rs697580	1:57,477,034	G/C	—	benign
rs17450764	1:57,477,150	G/A	—	benign
rs944923	1:57,480,424	C/G	—	benign
rs183171115	1:57,480,548	G/T	—	likely benign
rs368712456	1:57,480,629	G/A	—	likely benign
rs372127804	1:57,480,649	C/T	—	uncertain significance
rs1646379619	1:57,480,690	G/A	—	uncertain significance
rs144347021	1:57,480,714	C/T	—	uncertain significance
rs375940905	1:57,480,724	C/T	—	uncertain significance
rs144727413	1:57,480,728	C/T	—	likely benign
rs755254023	1:57,480,821	C/T	—	likely benign
rs374160257	1:57,480,832	C/T	—	uncertain significance
rs187717534	1:57,480,844	G/A	—	uncertain significance
rs200585955	1:57,480,874	G/C	—	uncertain significance
rs148158311	1:57,480,896	G/A	—	likely benign
rs1186883392	1:57,480,909	G/C	—	uncertain significance
rs746363033	1:57,480,925	C/T	—	likely benign
rs143089981	1:57,480,926	G/A	—	likely benign
rs752475579	1:57,480,969	G/A	—	uncertain significance
rs1049719265	1:57,480,983	G/A	—	likely benign
rs770270572	1:57,480,999	G/A	—	uncertain significance
rs199793708	1:57,481,012	C/T	—	conflicting classifications of pathogenicity
rs561439816	1:57,481,018	G/A	—	uncertain significance
rs1646395597	1:57,481,036	C/A	—	uncertain significance
rs12404008	1:57,481,076	C/T	—	likely benign
rs2523170947	1:57,481,102	A/G	—	uncertain significance
rs11810899	1:57,481,284	C/T	—	benign
rs3738558	1:57,489,137	T/C	—	benign
rs1001310743	1:57,489,224	C/T	—	uncertain significance
rs200606976	1:57,489,225	C/T	—	likely benign
rs34341631	1:57,489,239	T/C	—	benign
rs138384213	1:57,489,261	G/A	—	likely benign
rs149218415	1:57,489,266	G/T	—	uncertain significance
rs532864586	1:57,489,306	C/T	—	likely benign
rs115106157	1:57,489,506	G/A	—	benign
rs3820579	1:57,489,529	A/C	—	benign
rs190280115	1:57,491,668	T/C	—	uncertain significance
rs1646774558	1:57,491,677	G/A	—	likely pathogenic
rs764844188	1:57,499,236	G/A	—	likely benign
rs112325306	1:57,517,780	C/T	intron variant	—
rs35111731	1:57,525,372	A/G	intron variant	—
rs61364770	1:57,528,523	C/T	—	benign
rs141893131	1:57,528,562	C/G	—	uncertain significance
rs755221243	1:57,528,610	T/G	—	uncertain significance
rs778399446	1:57,528,611	G/A	—	likely benign
rs1261611	1:57,528,772	A/G	—	benign
rs375720863	1:57,535,053	T/C	—	uncertain significance
rs770014434	1:57,535,061	T/C	—	uncertain significance
rs200048299	1:57,535,075	G/A	—	likely benign
rs1570632701	1:57,535,081	A/G	—	likely benign
rs3738556	1:57,535,198	A/C	—	benign
rs3820576	1:57,536,024	G/C	intron variant	—
rs17418461	1:57,536,582	T/C	—	benign
rs3738555	1:57,536,941	A/G	—	benign
rs12754054	1:57,537,062	G/A	—	benign
rs1405684687	1:57,537,239	T/C	—	uncertain significance
rs755412805	1:57,537,282	G/A	—	likely benign
rs200624826	1:57,537,317	G/A	—	likely benign
rs113673321	1:57,537,732	T/C	—	benign
rs12718424	1:57,537,755	C/G	—	benign
rs59848345	1:57,537,768	A/G	—	benign
rs769093224	1:57,537,946	G/A	—	likely benign
rs887789978	1:57,537,956	C/T	—	uncertain significance
rs570170859	1:57,538,035	A/G	—	conflicting classifications of pathogenicity
rs190682807	1:57,538,076	A/C	—	likely benign
rs867910518	1:57,538,096	G/A	—	benign
rs2100796663	1:57,602,230	C/T	—	uncertain significance
rs151141316	1:57,602,299	C/T	—	uncertain significance
rs1855377	1:57,602,311	C/T	—	benign
rs776275848	1:57,602,313	C/T	—	uncertain significance
rs564665	1:57,602,334	G/A	—	benign
rs563921	1:57,602,383	T/C	—	benign
rs756329038	1:57,611,048	C/T	—	uncertain significance
rs74074204	1:57,611,176	G/C	—	benign
rs55859809	1:57,611,195	T/C	—	benign
rs17115208	1:57,611,330	A/G	—	benign
rs17541203	1:57,625,932	T/C	intron variant	—
rs59459799	1:57,627,960	G/A	intron variant	—
rs1394397	1:57,656,611	A/G	intron variant	—
rs74834332	1:57,739,164	G/A	intron variant	—
rs199645763	1:57,756,628	A/G	—	likely benign
rs376587394	1:57,756,660	C/T	—	conflicting classifications of pathogenicity
rs749634644	1:57,756,661	G/A	—	likely benign
rs998926328	1:57,756,684	G/A	—	uncertain significance
rs76376472	1:57,756,842	C/A	—	benign
rs595513	1:57,756,980	T/G	—	benign
rs595568	1:57,757,017	A/T	—	benign
rs79582403	1:57,757,041	A/C	—	benign
rs55863020	1:57,802,636	A/C	intron variant	—
rs10159302	1:57,805,550	A/C	intron variant	—
rs1424470	1:57,813,022	G/A	intron variant	—
rs12126723	1:57,814,331	C/A	—	—
rs11588755	1:57,819,204	G/A	intron variant	—

Showing 100 of 136 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.