rs62562210

This variant is located in the ASTN2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

restless legs syndrome

Schormair B et al. “Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.” Nature Genetics 56(6):1090-1099 (2024)

Allele A

OR 0.09

p 9.0e-43

N 1,663,113

Large GWAS

European

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 9.0e-21

N 2,669,029

Large GWAS

European

About ASTN2

This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]

View all ASTN2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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