rs6761276

This is a protein-altering variant in the IL1F10 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

C-reactive protein measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele C
OR 0.03
p 3.0e-28
N 355,127
Major Consortium StudyLarge GWAS
multi-ancestry

interleukin-1 receptor antagonist protein measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR —
β 0.190
p 2.0e-14
N 3,301
Large GWAS
European

interleukin 1 receptor antagonist measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele T
OR 0.22
p 1.0e-13
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)

level of serum globulin type protein

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele C
OR 0.02
p 4.0e-13
N 325,292
Major Consortium StudyLarge GWAS
multi-ancestry

fractalkine measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.04
p 7.0e-13
N 47,745
Large GWAS
European

myocardial infarction

Hartiala JA et al. “Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.” European Heart Journal 42(9):919-933 (2021)
Allele T
OR 1.04
p 3.0e-8
N 639,221
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes
AssociationN=16,292Rafiq S. et al.(2008)· Diabetologia

A meta-analysis of 4,107 type 2 diabetes cases and 5,187 controls from three GWA studies found no evidence that common variants altering circulating inflammatory protein levels (IL-18, IL-6R, CRP, IL1RN, PAI1, MIF) or variants predisposing to autoimmune diseases (type 1 diabetes, rheumatoid arthritis, Crohn's disease, celiac disease, multiple sclerosis, SLE) are associated with type 2 diabetes risk. For example, rs2250417 in IL18 showed OR=1.00 (95% CI 0.99-1.03) versus the expected OR of ~1.15 if inflammation were causal, suggesting inflammatory markers are likely secondary rather than causative in type 2 diabetes.

Traits studied:Ankylosing spondylitisAutoimmune diseasesC-reactive protein levelsCeliac diseaseCoeliac diseaseCrohn's diseaseIL-1 receptor antagonist levelsIL-18 levelsIL-6 levelsInflammatory diseasesInflammatory protein levelsMacrophage migration inhibitory factor levelsMultiple sclerosisPlasminogen activator inhibitor-1 levelsRheumatoid arthritisSystemic lupus erythematosusType 1 diabetesType 2 diabetes
PubMedDOIMetascience Observatory

About IL1F10

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

View all IL1F10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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