rs6976111
This variant is located in the CTTNBP2 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
social interaction measurement
Bralten J et al. “Genetic underpinnings of sociability in the general population.” Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 46(9):1627-1634 (2021)
Allele A
OR —
β 0.015
p 4.0e-10
N 342,461
Large GWAS
European
type 2 diabetes mellitus
Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)
Allele C
OR 0.03
p 8.0e-10
N 1,114,458
Meta-analysisLarge GWAS
European
Mahajan A et al. “Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.” Nature Genetics 50(11):1505-1513 (2018)
Allele C
OR 1.04
p 1.0e-8
N 898,130
Large GWAS
European
neuroticism measurement
Hill WD et al. “Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.” Molecular Psychiatry 25(11):3034-3052 (2020)
Allele C
OR 0.01
p 4.0e-9
N 270,059
Large GWAS
European
neurotic disorder
Cai N et al. “Minimal phenotyping yields genome-wide association signals of low specificity for major depression.” Nature Genetics 52(4):437-447 (2020)
Allele A
OR 0.01
p 1.0e-8
N 274,107
Large GWAS
European
About CTTNBP2
This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq, Jul 2008]
View all CTTNBP2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…