rs6986
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
guilt measurement
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele C
OR 7.25
p 4.0e-13
N 373,380
Large GWAS
European
anxiety measurement
Thorp JG et al. “Symptom-level modelling unravels the shared genetic architecture of anxiety and depression.” Nature Human Behaviour 5(10):1432-1442 (2021)
Allele G
OR 0.02
p 1.0e-12
N 136,957
Large GWAS
European
polyunsaturated fatty acid measurement
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele C
OR —
p 6.0e-11
N 239,268
Large GWAS
European
neuroticism measurement
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele C
OR 6.16
p 7.0e-10
N 380,506
Large GWAS
European
Luciano M et al. “Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.” Nature Genetics 50(1):6-11 (2018)
Allele C
OR 5.76
p 8.0e-9
N 329,821
Large GWAS
European
saturated fatty acids measurement
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele C
OR —
p 4.0e-9
N 239,268
Large GWAS
European
fatty acid amount
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele C
OR —
p 2.0e-10
N 239,268
Large GWAS
European
▶Research that mentions this SNP (1)
▶Genetic association analyses of non-synonymous single nucleotide polymorphisms in diabetic nephropathyAssociationN=1,711Savage DA et al.(2008)· Diabetologia
Genetic association analyses of non-synonymous single nucleotide polymorphisms in diabetic nephropathy
AssociationN=1,711Savage DA et al.(2008)· Diabetologia
This case-control study investigated 1,111 non-synonymous SNPs in 1,711 type 1 diabetic individuals (894 cases with diabetic nephropathy, 817 controls) to assess genetic susceptibility to diabetic nephropathy. After correction for multiple testing, no SNPs demonstrated significant associations with diabetic nephropathy, including in subgroup analyses by ESRD status or diabetes duration.
Traits studied:Diabetic nephropathyEnd-stage renal disease (ESRD)
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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